![]() AM and KI are employees of CLINICAL STUDY SUPPORT, Inc. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: TI and NK are founders of CLINICAL STUDY SUPPORT, Inc. for data collection and analysis as well as reporting. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: CLINICAL STUDY SUPPORT, Inc., which some authors belong to, was funded by Sanofi.K.K. Received: JAccepted: NovemPublished: December 12, 2014Ĭopyright: © 2014 Isomura et al. PLoS ONE 9(12):Įditor: Roland Seifert, Medical School of Hannover, Germany (2014) Central Nervous System Effects of the Second-Generation Antihistamines Marketed in Japan -Review of Inter-Drug Differences Using the Proportional Impairment Ratio (PIR). Sternberg S (1969) Memory scanning: mental processes revealed by reaction time experiments.Citation: Isomura T, Kono T, Hindmarch I, Kikuchi N, Murakami A, Inuzuka K, et al. Spector SL, Altman R (1987) Cetirizine, a novel antihistamine. Seidel WF, Cohen S, Bliwise NG, Dement WC (1987) Cetirizine effects on objective measures of daytime sleepiness and performance. Institute for Drugs, Safety and Behavior IGVG 90-08 Riedel WJ, Ramaekers JG, Uiterwijk M, O'Hanlon JF (1990) Higher doses of terfenadine and loratadine acute and subchronic effects on psychomotor and actual driving performance. O'Hanlon JF (1984) Driving performance under the influence of drugs, a rationale for, and application of, a new test. Norusis MJ (1986) SPSS/PC + Advanced Statistics. Moskowitz H (1973) Laboratory studies of the effects of alcohol on some variables related to driving. Monroe EW (1988) Chronic urticaria: Review of nonsedating H, antihistamines in treatment. In: Noordzij PZ, Roszbach R (ed) Alcohol, drugs and traffic safety. Louwerens JW, Gloerich ABM, Vries de G, Brookhuis KA, O'Hanlon JF (1987) The relationship between drivers' blood alcohol concentration (BAC) and actual driving performance during high speed travel. Jex HR, McDonnell JD (1966) Critical tracking task for manual control research. Electroenceph Clin Neurophysiol 10: 371–376 Jasper HH (1958) The ten twenty electrode system of the International Federation. Hilbert J, Radwanski E, Weglein R, Luc van GP, Symchowicz S, Zampaglione N (1987) Pharmacokinetics and dose proportionality of loratadine. Godthelp J (1988) The limits of path error neglecting in straight lane driving. Gengo FM, Gabos C, Mechtler L (1990) Quantitative effects of cetirizine and diphenhydramine in mental performance measured using an automobile driving simulator. Percept Psychophysics 16: 143–146įroentjes W (1968) Factoren van invloed op de hoogte van het bloedalcoholgehalte. ![]() Drugs 40: 762–781Įriksen BA, Eriksen CW (1974) Effects of noise letters upon the identification of a target letter in a nonsearch task. Cambridge, UKĬampoli-Richards DM, Buckley MM-T, Fitton A (1990) Cetirizine: a review of its pharmacological properties and clinical potential in allergic rhinitis, pollen-induced asthma, and chronic urticaria. Paper presented at the joint annual meeting of the Canadian College of Neuropsychopharmacology and the British Association for Psychopharmacology. ![]() ![]() It was concluded that cetirizine, but not loratadine, generally caused mild impairment of performance after a single 10 mg dose.īetts T, Kenwood C, Dalby G, Hull B, Wild J (1988) A comparison of the effects of two non-sedating antihistamines (terfenadine and cetirizine) on tests of CNS function (including driving). Loratadine had no significant effect on any performance parameter. Certain cetirizine-placebo differences in subjective feelings and test battery performance were also significant. The effects of alcohol and cetirizine appeared to be additive. It caused the subjects to operate with significantly greater variability in speed and lateral position (‘weaving’ motion). The effects of cetirizine of on driving performance resembled those of alcohol. Alcohol significantly affected almost every performance measure and altered the EEG energy spectrum during driving whilst the blood concentrations declined from 0.37 to 0.20 mg Performance was measured in two repetitions of a psychometric test battery, and a standard, over-the-road driving test. Sixteen healthy male and female volunteers took part in a 6-way, double-blind cross-over trial to compare the effects of single doses of cetirizine 10 mg, loratadine 10 mg and placebo, with and without alcohol (0.72 g
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